Background. This study evaluated the association between achieving target chronic kidney disease-mineral and bone disorder\n(CKD-MBD) marker levels andmortality in Taiwanese hemodialysis (HD) patients. Target levelswere based on the Kidney Disease:\nImproving Global Outcomes (KDIGO) guidelines. Methods. We performed a retrospective medical record review of 1126 HD\npatients between 2009 and 2013. A logistic regressionmodel was used to evaluate the relationship between achieving target marker\nlevels and the risk for all-cause and cardiovascular (CV)mortality. Reference target ranges were 7.9 � calcium (Ca) � 9.9mg/dL, 2.4\n� phosphate (P) � 4.7mg/dL, and 144 � intact parathyroid hormone (iPTH) � 648 pg/mL. Results. Achievement of target P levels\nwas associated with a lower risk for all-cause mortality compared to achievement of either target Ca or iPTH levels. Achieving\ntarget P + iPTH levels (OR 1.32) was associated with a lower odds ratio for all-cause mortality compared to achieving target Ca +\nP (OR 1.66) and Ca + iPTH (OR 1.43) levels. Similar trends were observed for CV mortality risk. Conclusions. The present study\ndemonstrated that achieving serum P levels within the KDIGO target range is the most important factor for lowering mortality in\nHD patients.
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